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Article

Genetic analysis of innate immunity: identification and function of the TIR adapter proteins.

Advances in experimental medicine and biology - 1 Jan 2005

Beutler Bruce, Hoebe Kasper, Georgel Philippe, Tabeta Koichi, Du Xin

Abstract excerpt

The innate immune system senses pathogens largely through signals initiated by a collection of phylogenetically related proteins known as "Toll-like receptors" (TLRs), of which ten representatives are encoded in the human genome. The sensing role of the TLRs first came to light when one member of this family, TLR4, was shown to serve the detection of endotoxin (lipopolysaccharide; LPS) in mice. This discovery was...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Adaptor Proteins, Vesicular Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigens, Differentiation

Share to Immunity, Innate

Share to Membrane Glycoproteins

Share to Myeloid Differentiation Factor 88

Share to Receptors, Immunologic

Share to Receptors, Interleukin-1

Source

Identifiers

PMID: 15934170
DOI: 10.1007/0-387-24180-9_4

Genes

TLR3
TLR4

Provenance

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