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Article

Competition between Heterochromatic Loci Allows the Abundance of the Silencing Protein, Sir4, to Regulate de novo Assembly of Heterochromatin.

PLoS genetics - 1 Nov 2015

Larin Michelle L, Harding Katherine, Williams Elizabeth C, Lianga Noel, Doré Carole, Pilon Sophie, Langis Éric, Yanofsky Corey, Rudner Adam D

Abstract excerpt

Changes in the locations and boundaries of heterochromatin are critical during development, and de novo assembly of silent chromatin in budding yeast is a well-studied model for how new sites of heterochromatin assemble. De novo assembly cannot occur in the G1 phase of the cell cycle and one to two divisions are needed for complete silent chromatin assembly and transcriptional repression. Mutation of DOT1, the...

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Source

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Identifiers

PMID: 26587833
DOI: 10.1371/journal.pgen.1005425
PMCID: PMC4654584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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