Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states.

Cell reports - 2 Nov 2021

Murawska Magdalena, Greenstein R A, Schauer Tamas, Olsen Karl C F, Ng Henry, Ladurner Andreas G, Al-Sady Bassem, Braun Sigurd

Abstract excerpt

Heterochromatin formation requires three distinct steps: nucleation, self-propagation (spreading) along the chromosome, and faithful maintenance after each replication cycle. Impeding any of those steps induces heterochromatin defects and improper gene expression. The essential histone chaperone FACT (facilitates chromatin transcription) has been implicated in heterochromatin silencing, but the mechanisms by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aminopeptidases
Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterochromatin

Share to Histone Chaperones

Share to Histone-Lysine N-Methyltransferase

Share to Methylation

Share to Schizosaccharomyces

Share to Schizosaccharomyces pombe Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 34731638
DOI: 10.1016/j.celrep.2021.109944
PMCID: PMC8608617

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states.PMID 34731638Read ↗

Rapid epigenetic adaptation to uncontrolled heterochromatin spreading.Semantic proximity Read ↗

The Histone Chaperones FACT and Spt6 Restrict H2A.Z from Intragenic Locations.Semantic proximity Read ↗

Essential histone chaperones collaborate to regulate transcription and chromatin integrity.Semantic proximity Read ↗

SNF2 Family Protein Fft3 Suppresses Nucleosome Turnover to Promote Epigenetic Inheritance and Proper Replication.Semantic proximity Read ↗

The FACT histone chaperone guides histone H4 into its nucleosomal conformation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Insight into the mechanism of nucleosome reorganization from histone mutants that suppress defects in the FACT histone chaperone.Semantic proximity Read ↗

The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription-replication conflicts.Semantic proximity Read ↗

The fork protection complex promotes parental histone recycling and epigenetic memory.Semantic proximity Read ↗

Spt6 prevents transcription-coupled loss of posttranslationally modified histone H3.Semantic proximity Read ↗

FACT sets a barrier for cell fate reprogramming in <i>C. elegans</i> and HumanSemantic proximity Read ↗

The FACT chromatin modulator: genetic and structure/function relationships.Semantic proximity Read ↗

FACT and the reorganized nucleosome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.