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Article

Multiple histone modifications in euchromatin promote heterochromatin formation by redundant mechanisms in Saccharomyces cerevisiae.

BMC molecular biology - 28 Jul 2009

Verzijlbergen Kitty F, Faber Alex W, Stulemeijer Iris Je, van Leeuwen Fred

Abstract excerpt

BACKGROUND: Methylation of lysine 79 on histone H3 by Dot1 is required for maintenance of heterochromatin structure in yeast and humans. However, this histone modification occurs predominantly in euchromatin. Thus, Dot1 affects silencing by indirect mechanisms and does not act by the recruitment model commonly proposed for histone modifications. To better understand the role of H3K79 methylation gene silencing,...

Topics

Gene Deletion
Gene Expression Regulation, Fungal
Gene Silencing
Heterochromatin
Histone Acetyltransferases
Histone Deacetylases
Histone-Lysine N-Methyltransferase
Histones
Nuclear Proteins
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Silent Information Regulator Proteins, Saccharomyces cerevisiae

Sirtuin 2

Sirtuins

Source

Open in PubMed Open full text

Identifiers

PMID: 19638198
DOI: 10.1186/1471-2199-10-76
PMCID: PMC2724485

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-19638198-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Multiple histone modifications in euchromatin promote heterochromatin formation by redundant mechanisms in Saccharomyces cerevisiae.PMID 19638198Read ↗

Dot1p modulates silencing in yeast by methylation of the nucleosome core.Semantic proximity Read ↗

The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure.Semantic proximity Read ↗

Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association.Semantic proximity Read ↗

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Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast.Semantic proximity Read ↗

Role for the silencing protein Dot1 in meiotic checkpoint control.Semantic proximity Read ↗

Competition between Heterochromatic Loci Allows the Abundance of the Silencing Protein, Sir4, to Regulate de novo Assembly of Heterochromatin.Semantic proximity Read ↗

Multiple SET methyltransferases are required to maintain normal heterochromatin domains in the genome of Drosophila melanogaster.Semantic proximity Read ↗

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H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases.Semantic proximity Read ↗

Position-effect variegation, heterochromatin formation, and gene silencing in Drosophila.Semantic proximity Read ↗

Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9.Semantic proximity Read ↗

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