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Article

An H3K9 methylation-dependent protein interaction regulates the non-enzymatic functions of a putative histone demethylase.

eLife - 20 Mar 2020

Raiymbek Gulzhan, An Sojin, Khurana Nidhi, Gopinath Saarang, Larkin Ajay, Biswas Saikat, Trievel Raymond C, Cho Uhn-Soo, Ragunathan Kaushik

Abstract excerpt

H3K9 methylation (H3K9me) specifies the establishment and maintenance of transcriptionally silent epigenetic states or heterochromatin. The enzymatic erasure of histone modifications is widely assumed to be the primary mechanism that reverses epigenetic silencing. Here, we reveal an inversion of this paradigm where a putative histone demethylase Epe1 in fission yeast, has a non-enzymatic function that opposes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32195666
DOI: 10.7554/eLife.53155
PMCID: PMC7192584

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