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Article

The human decapping scavenger enzyme DcpS modulates microRNA turnover.

Scientific reports - 20 Nov 2015

Meziane Oussama, Piquet Sandra, Bossé Gabriel D, Gagné Dominic, Paquet Eric, Robert Claude, Tones Michael A, Simard Martin J

Abstract excerpt

The decapping scavenger enzyme DcpS is known for its role in hydrolyzing the cap structure following mRNA degradation. Recently, we discovered a new function in miRNA degradation activation for the ortholog of DcpS in C. elegans. Here we show that human DcpS conserves its role in miRNA turnover. In human cells, DcpS is a nucleocytoplasmic shuttling protein that activates miRNA degradation independently of its...

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Identifiers

PMID: 26584588
DOI: 10.1038/srep16688
PMCID: PMC4653633

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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