Article

mRNA-decapping associated DcpS enzyme controls critical steps of neuronal development

2021-05-11

Abstract excerpt

Homozygous mutations in the gene encoding the scavenger mRNA-decapping enzyme, DcpS, have been shown to underlie developmental delay and intellectual disability. Intellectual disability is associated with both abnormal neocortical development and mRNA metabolism. However, the role of DcpS and its scavenger decapping activity in neuronal development is unknown. Here, we show that human neurons derived from patients...

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Literature Corpus work: f6bc6bfe-838e-51f6-9335-da0a840f3a30
DOI: 10.1101/2021.05.10.443481

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