Article

Discovery of cellular substrates of human RNA decapping enzyme Dcp2 using a stapled bicyclic peptide inhibitor

2020-11-02

Abstract excerpt

Dcp2 is an important enzyme that controls the stability of a subset of human cellular RNAs encoding functions such as transcription and immune responses. While >1800 Dcp2 substrates have been identified in human cells, compensatory gene expression changes secondary to genetic ablation of the DCP2 gene have complicated a complete mapping of its regulome. Cellpermeable, selective chemical ligands of Dcp2 could facil...

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Literature Corpus work: 2c55a627-fad9-57cf-8303-613a69bbea40
DOI: 10.26434/chemrxiv.12233102.v4

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