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Article

Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay.

Molecular and cellular biology - 1 Dec 2002

Lykke-Andersen Jens

Abstract excerpt

Decapping is a key step in general and regulated mRNA decay. In Saccharomyces cerevisiae it constitutes a rate-limiting step in the nonsense-mediated decay pathway that rids cells of mRNAs containing premature termination codons. Here two human decapping enzymes are identified, hDcp1a and hDcp2, as well as a homolog of hDcp1a, termed hDcp1b. Transiently expressed hDcp1a and hDcp2 proteins localize primarily to...

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Identifiers

PMID: 12417715
DOI: 10.1128/MCB.22.23.8114-8121.2002
PMCID: PMC134073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay.PMID 12417715Read ↗

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