Article

DCPS modulates TDP-43 mediated neurodegeneration through P-body regulation

2025-06-15

Abstract excerpt

<h4>SUMMARY</h4> The proteinopathy of the RNA-binding protein TDP-43, characterized by nuclear clearance and cytoplasmic inclusion, is a hallmark of multiple neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer’s disease (AD). Through CRISPR interference (CRISPRi) screening in human neurons, we identified the decapping enzyme scavenger (DCPS) as a...

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Literature Corpus work: d77f80b1-eb1c-56e8-bf15-b6a733822874
DOI: 10.1101/2025.06.13.659508

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