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Article

Control of mRNA decapping by positive and negative regulatory elements in the Dcp2 C-terminal domain.

RNA (New York, N.Y.) - 1 Sept 2015

He Feng, Jacobson Allan

Abstract excerpt

Decapping commits an mRNA to complete degradation and promotes general 5' to 3' decay, nonsense-mediated decay (NMD), and transcript-specific degradation. In Saccharomyces cerevisiae, a single decapping enzyme composed of a regulatory subunit (Dcp1) and a catalytic subunit (Dcp2) targets thousands of distinct substrate mRNAs. However, the mechanisms controlling this enzyme's in vivo activity and substrate...

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Identifiers

PMID: 26184073
DOI: 10.1261/rna.052449.115
PMCID: PMC4536323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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