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Article

Mechanistic and kinetic analysis of the DcpS scavenger decapping enzyme.

The Journal of biological chemistry - 13 Jun 2008

Liu Shin-Wu, Rajagopal Vaishnavi, Patel Smita S, Kiledjian Megerditch

Abstract excerpt

Decapping is an important process in the control of eukaryotic mRNA degradation. The scavenger decapping enzyme DcpS functions to clear the cell of cap structure following decay of the RNA body by catalyzing the hydrolysis of m(7)GpppN to m(7)Gp and ppN. Structural analysis has revealed that DcpS is a dimeric protein with a domain-swapped amino terminus. The protein dimer contains two cap binding/hydrolysis sites...

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Identifiers

PMID: 18441014
DOI: 10.1074/jbc.M800341200
PMCID: PMC2423256

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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