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Article

Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2016

Skeldon Alexander M, Morizot Alexandre, Douglas Todd, Santoro Nicola, Kursawe Romy, Kozlitina Julia, Caprio Sonia, Mehal Wajahat Z, Saleh Maya

Abstract excerpt

Inflammation is well established to significantly impact metabolic diseases. The inflammatory protease caspase-1 has been implicated in metabolic dysfunction; however, a potential role for the related inflammatory caspases is currently unknown. In this study, we investigated a role for caspase-11 and caspase-12 in obesity and insulin resistance. Loss of caspase-12 in two independently generated mouse strains...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26582949
DOI: 10.4049/jimmunol.1501529
PMCID: PMC5594569

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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