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Article

Systemic inflammation and insulin sensitivity in obese IFN-γ knockout mice.

Metabolism: clinical and experimental - 1 Aug 2012

O'Rourke Robert W, White Ashley E, Metcalf Monja D, Winters Brian R, Diggs Brian S, Zhu Xinxia, Marks Daniel L

Abstract excerpt

Adipose tissue macrophages are important mediators of inflammation and insulin resistance in obesity. IFN-γ is a central regulator of macrophage function. The role of IFN-γ in regulating systemic inflammation and insulin resistance in obesity is unknown. We studied obese IFN-γ knockout mice to identify the role of IFN-γ in regulating inflammation and insulin sensitivity in obesity. IFN-γ-knockout C57Bl/6 mice and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22386937
DOI: 10.1016/j.metabol.2012.01.018
PMCID: PMC3457921

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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