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Article

Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes.

Genes - 24 Sept 2023

Nejat Shadi, Menikdiwela Kalhara R, Efotte Aliyah, Scoggin Shane, Vandanmagsar Bolormaa, Thornalley Paul J, Dehbi Mohammed, Moustaid-Moussa Naima

Abstract excerpt

Several pathways and/or genes have been shown to be dysregulated in obesity-induced insulin resistance (IR) and type 2 diabetes (T2D). We previously showed, for the first time, impaired expression of DNAJB3 mRNA and protein in subjects with obesity, which was concomitant with increased metabolic stress. Restoring the normal expression of DNAJB3 attenuated metabolic stress and improved insulin signaling both in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37895206
DOI: 10.3390/genes14101857
PMCID: PMC10606339

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