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Article

Genetic control of ATGL-mediated lipolysis modulates adipose triglyceride stores in leptin-deficient mice.

Journal of lipid research - 1 May 2012

Marcelin Genevieve, Liu Shun-Mei, Li Xiaosong, Schwartz Gary J, Chua Streamson

Abstract excerpt

Dissecting the genetics of complex traits such as obesity allows the identification of causal genes for disease. Here, we show that the BALB/c mouse strain carries genetic variants that confer resistance to obesity induced by leptin-deficiency or a high-fat diet (HFD). We set out to identify the physiological and genetic bases underlying this phenotype. When compared with C57BL6/J ob/ob mice (B6), BALB/c ob/ob...

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Share to Adipocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22383686
DOI: 10.1194/jlr.M022467
PMCID: PMC3329395

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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