Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adipose tissue-selective ablation of ADAM10 results in divergent metabolic phenotypes following long-term dietary manipulation.

Adipocyte - 1 Dec 2024

Marino Luigi, Ni Bin, Farrar Jared S, Lownik Joseph C, Pearce Janina V, Martin Rebecca K, Celi Francesco S

Abstract excerpt

A Disintegrin And Metalloproteinase domain-containing protein 10 (ADAM10), is involved in several metabolic and inflammatory pathways. We speculated that ADAM10 plays a modulatory role in adipose tissue inflammation and metabolism. To this end, we studied adipose tissue-specific ADAM10 knock-out mice (aKO). While young, regular chow diet-fed aKO mice showed increased insulin sensitivity, following prolonged...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipocytes
Share to Adipose Tissue

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid Precursor Protein Secretases

Share to Diet, High-Fat

Share to Inflammation

Share to Insulin Resistance

Share to Mice, Knockout

Share to Obesity

Source

Open in PubMed Open full text

Identifiers

PMID: 38706095
DOI: 10.1080/21623945.2024.2339418
PMCID: PMC11073419

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adipose tissue-selective ablation of ADAM10 results in divergent metabolic phenotypes following long-term dietary manipulation.PMID 38706095Read ↗

Knockdown of a disintegrin A metalloprotease 12 (ADAM12) during adipogenesis reduces cell numbers, delays differentiation, and increases lipid accumulation in 3T3-L1 cellsSemantic proximity Read ↗

Depletion of regulator-of-G-protein signaling-10 in mice exaggerates high-fat diet-induced insulin resistance and inflammation, and this effect is mitigated by dietary green tea extract.Semantic proximity Read ↗

Diabetes genes identified by genome-wide association studies are regulated in mice by nutritional factors in metabolically relevant tissues and by glucose concentrations in islets.Semantic proximity Read ↗

Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice.Semantic proximity Read ↗

An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exerciseSemantic proximity Read ↗

Adiposity and metabolic health in mice deficient in intestinal alkaline phosphatase.Semantic proximity Read ↗

Acute loss of adipose tissue-derived adiponectin triggers immediate metabolic deterioration in mice.Semantic proximity Read ↗

ADAM17_i33708A>G polymorphism interacts with dietary n-6 polyunsaturated fatty acids to modulate obesity risk in the Genetics of Lipid Lowering Drugs and Diet Network study.Semantic proximity Read ↗

Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice.Semantic proximity Read ↗

Systemic inflammation and insulin sensitivity in obese IFN-γ knockout mice.Semantic proximity Read ↗

Improved insulin sensitivity despite increased visceral adiposity in mice deficient for the immune cell transcription factor T-bet.Semantic proximity Read ↗

Maternal high-fat diet exaggerates diet-induced insulin resistance in adult offspring by enhancing inflammasome activation through noncanonical pathway of caspase-11Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.