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Article

Improved insulin sensitivity despite increased visceral adiposity in mice deficient for the immune cell transcription factor T-bet.

Cell metabolism - 2 Apr 2013

Stolarczyk Emilie, Vong Chi Teng, Perucha Esperanza, Jackson Ian, Cawthorne Michael A, Wargent Edward T, Powell Nick, Canavan James B, Lord Graham M, Howard Jane K

Abstract excerpt

Low-grade inflammation in fat is associated with insulin resistance, although the mechanisms are unclear. We report that mice deficient in the immune cell transcription factor T-bet have lower energy expenditure and increased visceral fat compared with wild-type mice, yet paradoxically are more insulin sensitive. This striking phenotype, present in young T-bet(-/-) mice, persisted with high-fat diet and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23562076
DOI: 10.1016/j.cmet.2013.02.019
PMCID: PMC3685808

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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