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Article

Cell Migration and Invadopodia Formation Require a Membrane-binding Domain of CARMIL2.

The Journal of biological chemistry - 15 Jan 2016

Lanier M Hunter, McConnell Patrick, Cooper John A

Abstract excerpt

CARMILs regulate capping protein (CP), a critical determinant of actin assembly and actin-based cell motility. Vertebrates have three conserved CARMIL genes with distinct functions. In migrating cells, CARMIL2 is important for cell polarity, lamellipodial assembly, ruffling, and macropinocytosis. In cells, CARMIL2 localizes with a distinctive dual pattern to vimentin intermediate filaments and to membranes at...

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Source

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Identifiers

PMID: 26578515
DOI: 10.1074/jbc.M115.676882
PMCID: PMC4714192

Genes

CARMIL2
CARMIL1
CARMIL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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