Article
A genetic dissection of Aip1p's interactions leads to a model for Aip1p-cofilin cooperative activities.
Molecular biology of the cell - 1 Apr 2006
Clark Michael G, Teply Joseph, Haarer Brian K, Viggiano Susan C, Sept David, Amberg David C
Abstract excerpt
Actin interacting protein 1 (Aip1p) and cofilin cooperate to disassemble actin filaments in vitro and are thought to promote rapid turnover of actin networks in vivo. The precise method by which Aip1p participates in these activities has not been defined, although severing and barbed-end capping of actin filaments have been proposed. To better describe the mechanisms and biological consequences of Aip1p...
Topics
- Actin Cytoskeleton
- Actins
- Amino Acid Sequence
- Amino Acid Substitution
- Binding Sites
- Cofilin 1
- Endocytosis
- Microfilament Proteins
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation