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Article

Mechanism for CARMIL protein inhibition of heterodimeric actin-capping protein.

The Journal of biological chemistry - 4 May 2012

Kim Taekyung, Ravilious Geoffrey E, Sept David, Cooper John A

Abstract excerpt

Capping protein (CP) controls the polymerization of actin filaments by capping their barbed ends. In lamellipodia, CP dissociates from the actin cytoskeleton rapidly, suggesting the possible existence of an uncapping factor, for which the protein CARMIL (capping protein, Arp2/3 and myosin-I linker) is a candidate. CARMIL binds to CP via two motifs. One, the CP interaction (CPI) motif, is found in a number of...

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Identifiers

PMID: 22411988
DOI: 10.1074/jbc.M112.345447
PMCID: PMC3346114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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