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GAS7 coordinates the activity of RAC1 and CDC42 to enhance macropinocytic surveillance and suppress motility in macrophages

2025-12-11

Abstract excerpt

Fluid uptake by macropinocytosis is central for the sentinel function of macrophages. However, how the actin network is organized at the cell surface to drive persistent membrane ruffling and macropinocytic cup formation remains unclear. Due to the high curvature of dorsal ruffles, we asked whether membrane curvature-associated proteins, such as those containing F-BAR domains, participate in this process. Here, le...

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Identifiers and source

Literature Corpus work
9710760d-792b-5b53-a7fe-e009559e1494
DOI
10.64898/2025.12.09.693239
Open publication

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GAS7 coordinates the activity of RAC1 and CDC42 to enhance macropinocytic surveillance and suppress motility in macrophagesDOI 10.64898/2025.12.09.693239
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