Article
The PDZ-binding motif of MCC is phosphorylated at position -1 and controls lamellipodia formation in colon epithelial cells.
Biochimica et biophysica acta - 1 Jun 2012
Pangon Laurent, Van Kralingen Christa, Abas Melissa, Daly Roger J, Musgrove Elizabeth A, Kohonen-Corish Maija R J
Abstract excerpt
In this study, we describe a new post-translational modification at position -1 of the PDZ-binding motif in the mutated in colorectal cancer (MCC) protein and its role in lamellipodia formation. Serine 828 at position -1 of this motif is phosphorylated, which is predicted to increase MCC binding affinity with the polarity protein Scrib. We show that endogenous MCC localizes at the active migratory edge of cells,...
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