Article
The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins.
The Journal of biological chemistry - 16 May 2003
Van Impe Katrien, De Corte Veerle, Eichinger Ludwig, Bruyneel Erik, Mareel Marc, Vandekerckhove Joël, Gettemans Jan
Abstract excerpt
Despite thorough structure-function analyses, it remains unclear how CapG, a ubiquitous F-actin barbed end capping protein that controls actin microfilament turnover in cells, is able to reside in the nucleus and cytoplasm, whereas structurally related actin-binding proteins are predominantly cytoplasmic. Here we report the molecular basis for the different subcellular localization of CapG, severin, and fragminP....
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