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Article

Mammalian CARMIL inhibits actin filament capping by capping protein.

Developmental cell - 1 Aug 2005

Yang Changsong, Pring Martin, Wear Martin A, Huang Minzhou, Cooper John A, Svitkina Tatyana M, Zigmond Sally H

Abstract excerpt

Actin polymerization in cells occurs via filament elongation at the barbed end. Proteins that cap the barbed end terminate this elongation. Heterodimeric capping protein (CP) is an abundant and ubiquitous protein that caps the barbed end. We find that the mouse homolog of the adaptor protein CARMIL (mCARMIL) binds CP with high affinity and decreases its affinity for the barbed end. Addition of mCARMIL to cell...

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Identifiers

PMID: 16054028
DOI: 10.1016/j.devcel.2005.06.008
PMCID: PMC2628720

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mammalian CARMIL inhibits actin filament capping by capping protein.PMID 16054028Read ↗

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