Article
Increased proportion of KIR3DS1 homozygotes in HIV-exposed uninfected individuals.
AIDS (London, England) - 12 Mar 2008
Boulet Salix, Sharafi Saeid, Simic Nancy, Bruneau Julie, Routy Jean-Pierre, Tsoukas Christos M, Bernard Nicole F
Abstract excerpt
OBJECTIVES: Natural killer (NK) cell activity is increased in individuals who remain uninfected despite repeated exposures to HIV. Given that a combined major histocompatibility complex (MHC) class I and killer immunoglobulin-like receptor (KIR) KIR3D genotype has been linked to rate of HIV disease progression, we assessed whether these genotypes played a role in protection from infection. DESIGN: The study...
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