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Article

Natural killer cell-mediated innate sieve effect on HIV-1: the impact of KIR/HLA polymorphism on HIV-1 subtype-specific acquisition in east Africa.

The Journal of infectious diseases - 15 Oct 2013

Koehler Rebecca N, Alter Galit, Tovanabutra Sodsai, Saathoff Elmar, Arroyo Miguel A, Walsh Anne M, Sanders-Buell Eric E, Maboko Leonard, Hoelscher Michael, Robb Merlin L, Michael Nelson L, McCutchan Francine E, Kim Jerome H, Kijak Gustavo H

Abstract excerpt

Here we explore the association between killer cell immunoglobulin-like receptor (KIR)/HLA and human immunodeficiency virus type 1 (HIV-1) acquisition with different viral subtypes circulating in East Africa. In the prospective Cohort Development (CODE) cohort (Mbeya, Tanzania), carriers of KIR3DS1 and its putative ligand (HLA-A or HLA-B Bw4-80Ile alleles) showed increased HIV-1 acquisition risk (odds ratio [OR]...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 23922366
DOI: 10.1093/infdis/jit349
PMCID: PMC3778971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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