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Article

HLA-Cw*0102-restricted HIV-1 p24 epitope variants can modulate the binding of the inhibitory KIR2DL2 receptor and primary NK cell function.

PLoS pathogens - 1 Jan 2012

Fadda Lena, Körner Christian, Kumar Swati, van Teijlingen Nienke H, Piechocka-Trocha Alicja, Carrington Mary, Altfeld Marcus

Abstract excerpt

Accumulating evidence suggests an important role for Natural Killer (NK) cells in the control of HIV-1 infection. Recently, it was shown that NK cell-mediated immune pressure can result in the selection of HIV-1 escape mutations. A potential mechanism for this NK cell escape is the selection of HLA class I-presented HIV-1 epitopes that allow for the engagement of inhibitory killer cell immunoglobulin-like...

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Share to Cytotoxicity, Immunologic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Core Protein p24

Share to HIV Infections

Share to HLA-C Antigens

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Share to Killer Cells, Natural

Share to Receptors, KIR2DL2

Source

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Identifiers

PMID: 22807681
DOI: 10.1371/journal.ppat.1002805
PMCID: PMC3395618

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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