Article
A combined genotype of KIR3DL1 high expressing alleles and HLA-B*57 is associated with a reduced risk of HIV infection.
AIDS (London, England) - 31 Jul 2008
Boulet Salix, Kleyman Marianna, Kim Jenice Yj, Kamya Philomena, Sharafi Saeid, Simic Nancy, Bruneau Julie, Routy Jean-Pierre, Tsoukas Christos M, Bernard Nicole F
Abstract excerpt
OBJECTIVES: Coexpression of certain combinations of natural killer cell receptor KIR3DL1 and HLA-B alleles is associated with slower time to AIDS. The strongest protection in terms of disease outcome in KIR3DL1 homozygotes (3DL1 hmz) is coexpression of HLA-B*57 and a set of KIR3DL1 genotypes (3DL1*h/*y) lacking alleles expressed at low levels on natural killer cells. We questioned whether this allele combination...
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