Article
Polymorphisms at Locus 4p14 of Toll-Like Receptors TLR-1 and TLR-10 Confer Susceptibility to Gastric Carcinoma in Helicobacter pylori Infection.
PloS one - 1 Jan 2015
Ravishankar Ram M, Goh Khean Lee, Leow Alex Hwong Ruey, Poh Bee Hoon, Loke Mun Fai, Harrison Richard, Shankar Esaki M, Vadivelu Jamuna
Abstract excerpt
Helicobacter pylori (H. pylori) -induced gastric inflammation impacts the functions of leptin- and ghrelin-producing cells in the gastroduodenum. Inflammation resulting from H. pylori sensing via Toll-like receptors (TLRs) and the associated downstream signaling largely remain ambiguous. Here, we investigated the role of gut hormones, pro-inflammatory cytokines and single nucleotide polymorphisms (SNPs)...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Chromosomes, Human, Pair 4
- Cytokines
- Female
- Genetic Predisposition to Disease
- Helicobacter Infections
- Helicobacter pylori
- Humans
- Leptin
- Male