Article
Genetic polymorphisms in the Toll-like receptor signalling pathway in Helicobacter pylori infection and related gastric cancer.
Human immunology - 1 Aug 2014
Castaño-Rodríguez Natalia, Kaakoush Nadeem O, Pardo Aryce L, Goh Khean-Lee, Fock Kwong Ming, Mitchell Hazel M
Abstract excerpt
BACKGROUND: Gastric cancer (GC) is a progressive process initiated by Helicobacter pylori-induced inflammation. Initial recognition of H. pylori involves Toll-like receptors (TLRs), central molecules in the host inflammatory response. Here, we investigated the association between novel polymorphisms in genes involved in the TLR signalling pathway, including TLR2, TLR4, LBP, MD-2, CD14 and TIRAP, and risk of H....
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