Article
TLR4 single-nucleotide polymorphisms alter mucosal cytokine and chemokine patterns in Mexican patients with Helicobacter pylori-associated gastroduodenal diseases.
Clinical immunology (Orlando, Fla.) - 1 Nov 2008
Trejo-de la O Alejandra, Torres Javier, Pérez-Rodríguez Martha, Camorlinga-Ponce Margarita, Luna L Flores, Abdo-Francis José M, Lazcano Eduardo, Maldonado-Bernal Carmen
Abstract excerpt
Helicobacter pylori is associated with peptic ulcer and gastric adenocarcinoma. Toll-like receptors (TLRs) participate in H. pylori recognition, and single-nucleotide polymorphisms (SNPs) in TLRs are associated with impaired immune response. We aimed to evaluate the association of TLR2/R753Q and TLR4/D299G/T399I SNPs with gastroduodenal diseases; and study the effect of SNPs on cytokine and chemokine expression...
Topics
- Adult
- Aged
- Case-Control Studies
- Chemokines
- Cytokines
- Duodenal Ulcer
- Female
- Gastritis
- Helicobacter Infections
- Helicobacter pylori