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Article

APC functions at the centrosome to stimulate microtubule growth.

The international journal of biochemistry & cell biology - 1 Jan 2016

Lui Christina, Ashton Cahora, Sharma Manisha, Brocardo Mariana G, Henderson Beric R

Abstract excerpt

The adenomatous polyposis coli (APC) tumor suppressor is multi-functional. APC is known to localize at the centrosome, and in mitotic cells contributes to formation of the mitotic spindle. To test whether APC contributes to nascent microtubule (MT) growth at interphase centrosomes, we employed MT regrowth assays in U2OS cells to measure MT assembly before and after nocodazole treatment and release. We showed that...

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Source

Identifiers

PMID: 26556314
DOI: 10.1016/j.biocel.2015.10.028

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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