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The centrosome cycle

30 May 2002

Abstract excerpt

The centrosome is the major microtubule-organizing center of animal cells. It influences cell shape and polarity and directs the formation of the bipolar mitotic spindle. Numerical and structural centrosome aberrations have been implicated in disease, notably cancer. In dividing cells, centrosomes need to be duplicated and segregated in synchrony with chromosomes. This centrosome cycle requires a series of...

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PMID: 12067716
DOI: 10.1016/s0014-5793(02)02865-x

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