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Article

APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment.

Molecular biology of the cell - 1 Oct 2005

Green Rebecca A, Wollman Roy, Kaplan Kenneth B

Abstract excerpt

Recently, we have shown that a cancer causing truncation in adenomatous polyposis coli (APC) (APC(1-1450)) dominantly interferes with mitotic spindle function, suggesting APC regulates microtubule dynamics during mitosis. Here, we examine the possibility that APC mutants interfere with the function of EB1, a plus-end microtubule-binding protein that interacts with APC and is required for normal microtubule...

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Source

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Identifiers

PMID: 16030254
DOI: 10.1091/mbc.e05-03-0259
PMCID: PMC1237068

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment.PMID 16030254Read ↗

Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization.Semantic proximity Read ↗

The APC-EB1 interaction.Semantic proximity Read ↗

Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells.Semantic proximity Read ↗

Mutual antagonism between the anaphase promoting complex and the spindle assembly checkpoint contributes to mitotic timing in Caenorhabditis elegans.Semantic proximity Read ↗

The adenomatous polyposis coli protein is required for the formation of robust spindles formed in CSF Xenopus extracts.Semantic proximity Read ↗

Spindle Microtubule Dysfunction and Cancer PredispositionSemantic proximity Read ↗

Mal3, the fission yeast homologue of the human APC-interacting protein EB-1 is required for microtubule integrity and the maintenance of cell form.Semantic proximity Read ↗

APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation.Semantic proximity Read ↗

Aurora-A phosphorylates Augmin complex component Hice1 protein at an N-terminal serine/threonine cluster to modulate its microtubule binding activity during spindle assembly.Semantic proximity Read ↗

APC functions at the centrosome to stimulate microtubule growth.Semantic proximity Read ↗

The dynamic localisation of the Drosophila APC/C: evidence for the existence of multiple complexes that perform distinct functions and are differentially localised.Semantic proximity Read ↗

XMAP215-EB1 interaction is required for proper spindle assembly and chromosome segregation in Xenopus egg extract.Semantic proximity Read ↗

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