Article

Beta-catenin mediates growth defects induced by centrosome loss in APC mutant colorectal cancer independently of p53

2023-02-16

Abstract excerpt

Colorectal cancer is the third most common cancer and the second leading cause of cancer-related deaths worldwide. The centrosome is the main microtubule-organizing center in animal cells and centrosome amplification is a hallmark of cancer cells. To investigate the importance of centrosomes in colorectal cancer, we induced centrosome loss in normal and cancer human-derived colorectal organoids using centrinone B,...

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Literature Corpus work: 0edcffa6-9faf-5e3c-b523-3188f169c2fe
DOI: 10.1101/2023.02.13.528233

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