Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The DNA replication protein Cdc6 inhibits the microtubule-organizing activity of the centrosome.

The Journal of biological chemistry - 29 Sept 2017

Lee Inyoung, Kim Gwang Su, Bae Jun Sung, Kim Jaeyoun, Rhee Kunsoo, Hwang Deog Su

Abstract excerpt

The centrosome serves as a major microtubule-organizing center (MTOC). The Cdc6 protein is a component of the pre-replicative complex and a licensing factor for the initiation of chromosome replication and localizes to centrosomes during the S and G2 phases of the cfell cycle of human cells. This cell cycle-dependent localization of Cdc6 to the centrosome motivated us to investigate whether Cdc6 negatively...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens
Share to Centrosome
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microscopy, Fluorescence

Share to Peptide Fragments

Share to RNA Interference

Share to Time-Lapse Imaging

Share to Tubulin

Source

Open in PubMed Open full text

Identifiers

PMID: 28827311
DOI: 10.1074/jbc.M116.763680
PMCID: PMC5625056

Genes

CDK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The DNA replication protein Cdc6 inhibits the microtubule-organizing activity of the centrosome.PMID 28827311Read ↗

The centrosome cycleSemantic proximity Read ↗

Orc6 involved in DNA replication, chromosome segregation, and cytokinesis.Semantic proximity Read ↗

Depletion of licensing inhibitor geminin causes centrosome overduplication and mitotic defects.Semantic proximity Read ↗

Cdc6 disruption leads to centrosome abnormalities and chromosome instability in pancreatic cancer cellsSemantic proximity Read ↗

GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation.Semantic proximity Read ↗

In vitro reconstitution of minimal human centrosomesSemantic proximity Read ↗

CDC25B Involvement in the Centrosome Duplication Cycle and in Microtubule NucleationSemantic proximity Read ↗

CDKs Promote DNA Replication Origin Licensing in Human Cells by Protecting Cdc6 from APC/C-Dependent ProteolysisSemantic proximity Read ↗

Distinct Sequence Elements of Cyclin B1 Promote Localization to Chromatin, Centrosomes, and Kinetochores during MitosisSemantic proximity Read ↗

Elevated Levels of Mcm7 Disrupt Microtubule and Nucleolar Homeostasis to Drive Genome Instability and Cell DeathSemantic proximity Read ↗

Compartmentalized control of Cdk1 drives mitotic spindle assemblySemantic proximity Read ↗

Cyclin E-dependent localization of MCM5 regulates centrosome duplicationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.