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Article

The adenomatous polyposis coli protein is required for the formation of robust spindles formed in CSF Xenopus extracts.

Molecular biology of the cell - 1 Jun 2004

Dikovskaya Dina, Newton Ian P, Näthke Inke S

Abstract excerpt

Mutations in the adenomatous polyposis coli (APC) protein occur early in colon cancer and correlate with chromosomal instability. Here, we show that depletion of APC from cystostatic factor (CSF) Xenopus extracts leads to a decrease in microtubule density and changes in tubulin distribution in spindles and asters formed in such extracts. Addition of full-length APC protein or a large, N-terminally truncated APC...

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Source

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Identifiers

PMID: 15075372
DOI: 10.1091/mbc.e03-08-0613
PMCID: PMC420119

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The adenomatous polyposis coli protein is required for the formation of robust spindles formed in CSF Xenopus extracts.PMID 15075372Read ↗

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