Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The adenomatous polyposis coli protein is required for the formation of robust spindles formed in CSF Xenopus extracts.

Molecular biology of the cell - 1 Jun 2004

Dikovskaya Dina, Newton Ian P, Näthke Inke S

Abstract excerpt

Mutations in the adenomatous polyposis coli (APC) protein occur early in colon cancer and correlate with chromosomal instability. Here, we show that depletion of APC from cystostatic factor (CSF) Xenopus extracts leads to a decrease in microtubule density and changes in tubulin distribution in sp...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli Protein
Share to Biological Factors
Share to Cell Extracts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Meiosis

Share to Microtubules

Share to Spindle Apparatus

Share to Tubulin

Share to Xenopus

Source

Open in PubMed Open full text

Identifiers

PMID: 15075372
DOI: 10.1091/mbc.e03-08-0613
PMCID: PMC420119

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15075372-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The adenomatous polyposis coli protein is required for the formation of robust spindles formed in CSF Xenopus extracts.PMID 15075372Read ↗

APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment.Semantic proximity Read ↗

Spindle Microtubule Dysfunction and Cancer PredispositionSemantic proximity Read ↗

APC functions at the centrosome to stimulate microtubule growth.Semantic proximity Read ↗

Role of APC and its binding partners in regulating microtubules in mitosis.Semantic proximity Read ↗

PLK1 has tumor-suppressive potential in APC-truncated colon cancer cellsSemantic proximity Read ↗

APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice.Semantic proximity Read ↗

Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability.Semantic proximity Read ↗

The drosophila protein asp is involved in microtubule organization during spindle formation and cytokinesis.Semantic proximity Read ↗

Adenomatous polyposis coli nucleates actin assembly to drive cell migration and microtubule-induced focal adhesion turnover.Semantic proximity Read ↗

The tumor suppressor APC is an attenuator of spindle-pulling forces during <i>C. elegans</i> asymmetric cell divisionSemantic proximity Read ↗

APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation.Semantic proximity Read ↗

Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.