Article
Mutational Profiling Can Establish Clonal or Independent Origin in Synchronous Bilateral Breast and Other Tumors.
PloS one - 1 Jan 2015
Bao Lei, Messer Karen, Schwab Richard, Harismendy Olivier, Pu Minya, Crain Brian, Yost Shawn, Frazer Kelly A, Rana Brinda, Hasteh Farnaz, Wallace Anne, Parker Barbara A
Abstract excerpt
BACKGROUND: Synchronous tumors can be independent primary tumors or a primary-metastatic (clonal) pair, which may have clinical implications. Mutational profiling of tumor DNA is increasingly common in the clinic. We investigated whether mutational profiling can distinguish independent from clonal tumors in breast and other cancers, using a carefully defined test based on the Clonal Likelihood Score (CLS = 100 x...
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