Testing clonal relatedness of two tumors from the same patient based on their mutational profiles: update of the Clonality R package.

Abstract excerpt

SUMMARY: The Clonality R package is a practical tool to assess the clonal relatedness of two tumors from the same patient. We have previously presented its functionality for testing tumors using loss of heterozygosity data or copy number arrays. Since then somatic mutation data have been more widely available through next generation sequencing and we have developed new methodology for comparing the tumors'...

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