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Article

Evaluating statistical approaches to define clonal origin of tumours using bulk DNA sequencing: context is everything.

Genome biology - 2 Feb 2022

Kader Tanjina, Zethoven Magnus, Gorringe Kylie L

Abstract excerpt

Clonal analysis of tumour sequencing data enables the evaluation of the relationship of histologically distinct synchronous lesions, such as co-existing benign areas, and temporally distinct tumours, such as primary-recurrence comparisons. In this review, we summarise statistical approaches that are commonly employed to define tumour clonal relatedness using data from bulk DNA technologies. We discuss approaches...

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Identifiers

PMID: 35109903
DOI: 10.1186/s13059-022-02600-6
PMCID: PMC8809045

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