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Article

Systematic investigation of the prognostic impact of clonal status of somatic mutations across multiple cancer types.

Genomics - 1 Jul 2022

Cheng Peng, Lan Yujia, Liao Jianlong, Zhao Erjie, Yan Haoteng, Xu Liwen, A Suru, Ping Yanyan, Xu Jinyuan

Abstract excerpt

Tumors are genetically heterogeneous and many mutations are actually present in subclonal populations. The clonal status of mutations is valuable for accurate prognosis, clinical management. The aim of this study was to identify the clonal status of somatic mutations and systematically evaluate their prognostic values across various cancer types. We totally identified 227 clonal and 432 subclonal mutations...

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PMID: 35714828
DOI: 10.1016/j.ygeno.2022.110412

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