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Article

Estimating the probability of clonal relatedness of pairs of tumors in cancer patients.

Biometrics - 1 Mar 2018

Mauguen Audrey, Seshan Venkatraman E, Ostrovnaya Irina, Begg Colin B

Abstract excerpt

Next generation sequencing panels are being used increasingly in cancer research to study tumor evolution. A specific statistical challenge is to compare the mutational profiles in different tumors from a patient to determine the strength of evidence that the tumors are clonally related, that is, derived from a single, founder clonal cell. The presence of identical mutations in each tumor provides evidence of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28482133
DOI: 10.1111/biom.12710
PMCID: PMC5677588

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