Article
Statistical tests for clonality.
Biometrics - 1 Jun 2007
Begg Colin B, Eng Kevin H, Hummer Amanda J
Abstract excerpt
Cancer investigators frequently conduct studies to examine tumor samples from pairs of apparently independent primary tumors with a view to determine whether they share a "clonal" origin. The genetic fingerprints of the tumors are compared using a panel of markers, often representing loss of heterozygosity (LOH) at distinct genetic loci. In this article we evaluate candidate significance tests for this purpose....
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