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Article

Comparative genomic analysis reveals bilateral breast cancers are genetically independent.

Oncotarget - 13 Oct 2015

Song Fangfang, Li Xiangchun, Song Fengju, Zhao Yanrui, Li Haixin, Zheng Hong, Gao Zhibo, Wang Jun, Zhang Wei, Chen Kexin

Abstract excerpt

Bilateral breast cancer (BBC) poses a major challenge for oncologists because of the cryptic relationship between the two lesions. The purpose of this study was to determine the origin of the contralateral breast cancer (either dependent or independent of the index tumor). Here, we used ultra-deep whole-exome sequencing and array comparative genomic hybridization (aCGH) to study four paired samples of BBCs with...

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Identifiers

PMID: 26378809
DOI: 10.18632/oncotarget.5569
PMCID: PMC4741642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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