Article
Association of Bitter Taste Receptor T2R38 Polymorphisms, Oral Microbiota, and Rheumatoid Arthritis.
Current issues in molecular biology - 9 Oct 2021
de Jesus Vivianne Cruz, Singh Manu, Schroth Robert J, Chelikani Prashen, Hitchon Carol A
Abstract excerpt
The association of taste genetics and the oral microbiome in autoimmune diseases such as rheumatoid arthritis (RA) has not been reported. We explored a novel oral mucosal innate immune pathway involving the bitter taste G protein-coupled receptor T2R38. This case-control study aimed to evaluate w...
Topics
- Adult
- Aged
- Alleles
- Arthritis, Rheumatoid
- Disease Susceptibility
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Microbiota
- Middle Aged
- Mouth Mucosa
- Polymorphism, Single Nucleotide
- RNA, Ribosomal, 16S
- Receptors, G-Protein-Coupled
- Taste Receptors, Type 2