Functional analysis of differences in transcriptional activity conferred by genetic variants in the 5' flanking region of the IL12RB2 gene.

doi:10.1007/s00251-015-0882-x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Functional analysis of differences in transcriptional activity conferred by genetic variants in the 5' flanking region of the IL12RB2 gene.

Immunogenetics - 1 Jan 2016

Kato-Kogoe Nahoko, Ohyama Hideki, Okano Soichiro, Yamanegi Koji, Yamada Naoko, Hata Masaki, Nishiura Hiroshi, Abiko Yoshimitsu, Terada Nobuyuki, Nakasho Keiji

Abstract excerpt

Interleukin 12 receptor β chain (IL12RB2) is a crucial regulatory factor involved in cell-mediated immune responses, and genetic variants of the gene encoding IL12RB2 are associated with susceptibility to various immune-related diseases. We previously demonstrated that haplotypes with single nucleotide polymorphisms (SNPs) in the 5' flanking region of IL12RB2, including -1035A>G (rs3762315) and -1023A>G...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Flanking Region

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to GATA3 Transcription Factor

Share to Jurkat Cells

Share to Killer Cells, Natural

Share to MEF2 Transcription Factors

Share to Receptors, Interleukin-12

Share to Transcription Factor AP-1

Share to Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 26552659
DOI: 10.1007/s00251-015-0882-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional analysis of differences in transcriptional activity conferred by genetic variants in the 5' flanking region of the IL12RB2 gene.PMID 26552659Read ↗

Differential effects of polymorphisms in the 5' flanking region of IL12RB2 on NK- and T-cell activity.Semantic proximity Read ↗

A novel polymorphic GATA site in the human IL-12Rbeta2 promoter region affects transcriptional activity.Semantic proximity Read ↗

Polymorphism of the 5' flanking region of the IL-12 receptor beta2 gene partially determines the clinical types of leprosy through impaired transcriptional activity.Semantic proximity Read ↗

An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation.Semantic proximity Read ↗

Functional haplotypes of IL-12B are associated with childhood atopic asthma.Semantic proximity Read ↗

Multiple single nucleotide polymorphisms in the first intron of the IL2RA gene affect transcription factor binding and enhancer activity.Semantic proximity Read ↗

Association of variants in the IL12B gene with leprosy and tuberculosis.Semantic proximity Read ↗

Polymorphisms in the 5' flanking region of IL12RB2 are associated with susceptibility to periodontal diseases in the Japanese population.Semantic proximity Read ↗

IL12RB2 Polymorphisms correlate with risk of lung adenocarcinoma.Semantic proximity Read ↗

Human IL12RB1 expression is allele-biased and produces a novel IL12 response regulator.Semantic proximity Read ↗

A functional variant in IL12B promoter modulates its expression and associates with increased risk of allergic asthma.Semantic proximity Read ↗

Differential expression and function of human IL-12Rβ2 polymorphic variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.