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Article

IL12RB2 Polymorphisms correlate with risk of lung adenocarcinoma.

Immunobiology - 1 Feb 2016

Prigione Ignazia, Covone Angela Elvira, Giacopelli Francesca, Bocca Paola, Risso Marco, Tripodi Gino, Pistorio Angela, Sozzi Gabriella, Airoldi Irma, Ravazzolo Roberto, Pistoia Vito

Abstract excerpt

In a previous study, lack of IL-12 signaling in il12rb2 knock-out mice was found to predispose to lung adenocarcinoma (LAC). We asked whether specific polymorphisms of the human IL12RB2 gene may confer susceptibility to LAC. We studied IL12RB2 single nucleotide polymorphisms (SNPs) spanning from the promoter to the first untranslated exon of the gene. Genotypes of 49 individuals with LAC were compared with those...

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PMID: 26547104
DOI: 10.1016/j.imbio.2015.10.006

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STAT4

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