Article
Functional haplotypes of IL-12B are associated with childhood atopic asthma.
The Journal of allergy and clinical immunology - 1 Oct 2005
Hirota Tomomitsu, Suzuki Yoichi, Hasegawa Koichi, Obara Kazuhiko, Matsuda Akira, Akahoshi Mitsuteru, Nakashima Kazuko, Cheng Lei, Takahashi Naomi, Shimizu Makiko, Doi Satoru, Fujita Kimie, Enomoto Tadao, Ebisawa Motohiro, Yoshihara Shigemi, Nakamura Yusuke, Kishi Fumio, Shirakawa Taro, Tamari Mayumi
Abstract excerpt
BACKGROUND: IL-12 is a heterodimeric proinflammatory cytokine that forms a link between innate and adaptive immunity. Although associations between polymorphisms of IL-12B on chromosome 5q31-33 and asthma have been reported, the genetic influences of the polymorphisms and haplotype of IL-12B are unclear. OBJECTIVE: To examine whether polymorphisms in IL-12B are associated with childhood atopic asthma in a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.