Article
An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation.
Annals of the rheumatic diseases - 1 Dec 2016
Roberts Amity R, Vecellio Matteo, Chen Liye, Ridley Anna, Cortes Adrian, Knight Julian C, Bowness Paul, Cohen Carla J, Wordsworth B Paul
Abstract excerpt
OBJECTIVES: To explore the functional basis for the association between ankylosing spondylitis (AS) and single-nucleotide polymorphisms (SNPs) in the IL23R-IL12RB2 intergenic region. METHODS: We performed conditional analysis on genetic association data and used epigenetic data on chromatin remodelling and transcription factor (TF) binding to identify the primary AS-associated IL23R-IL12RB2 intergenic SNP....
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